PDRN (Polydeoxyribonucleotide) is Korea’s skincare innovation for deep skin recovery, hydration, and improved firmness. Discover how PDRN works, the difference between serums and boosters, and shop top picks from Anua, Medicube, and VT Cosmetics. For a stronger, healthy-looking skin at every stage of recovery.
What is PDRN?
PDRN is a DNA fragment, originally extracted from salmon sperm. It sounds wild, but it’s a powerful ingredient that works deep within the skin to stimulate healing, cell renewal, and collagen production. You’ll find it in premium PDRN serums and PDRN skin boosters.
What Does PDRN Do for Your Skin?
- Stimulates cell regeneration and wound healing
- Improves skin elasticity and firmness
- Brightens dull skin and softens fine lines
- Soothes redness and sensitivity
How to Use a PDRN Skin Booster
Apply a PDRN serum after cleansing and before your moisturizer. For more intensive treatments, it can also be used with a microneedling device (recommended only for experienced users or professional treatments).
Who Should Use PDRN?
Anyone who wants to give their skin a serious boost. PDRN is especially beneficial for dull, weakened, or recovering skin that needs extra strength and resilience.
Recommended PDRN Products

Infused with PDRN, 11 types of hyaluronic acid, and collagen, this serum dives deep to plump fine lines, improve skin texture, and restore your natural glow – without stickiness!

This refreshing gel is ideal for sensitive or irritated skin. Packed with calming ingredients and PDRN, it helps reduce redness, strengthens the skin barrier, and evens out your complexion.
Frequently Asked Questions about PDRN
What’s the difference between a PDRN serum and a skin booster?
A PDRN serum is usually lighter and suitable for daily use. A PDRN skin booster contains a higher concentration of PDRN, designed for more intensive treatments or professional care.
Is salmon DNA safe for my skin?
Yes! PDRN (salmon DNA) is carefully purified and processed according to strict cosmetic regulations. It has been used safely for years in both medical and dermatological treatments.
Can I combine PDRN with other skincare ingredients?
Absolutely! PDRN works well with hydrating and soothing ingredients like hyaluronic acid, panthenol, and centella asiatica. If your skin is sensitive, it's best to avoid strong acids alongside PDRN.
Is there a vegan alternative to PDRN?
PDRN naturally comes from salmon DNA, so it is not vegan. As a plant-based alternative, look for skincare containing PHYTO PDRN® from ginseng, peptides, or centella asiatica.
Vegan Tip!
Did you know the VT Cosmetics PDRN Essence 100 offers a fully vegan alternative? It features PHYTO PDRN®PANAX derived from ginseng for hydration, resilience, and a natural glow – without animal ingredients.